Research

High phenolic olive oil research

Oleocanthal Combined with Lapatinib Treatment Synergized against HER-2 Positive Breast Cancer In Vitro and In Vivo

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412724/


Oleocanthal Prevents Breast Cancer Locoregional Recurrence After Primary Tumor Surgical Excision and Neoadjuvant Targeted Therapy in Orthotopic Nude Mouse Models

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562541/


The olive oil phenolic oleocanthal modulates estrogen receptor expression in luminal breast cancer in vitro and in vivo and synergizes with tamoxifen treatment.

https://www.ncbi.nlm.nih.gov/pubmed/28625568


Olive-oil-derived oleocanthal enhances β-amyloid clearance as a potential neuroprotective mechanism against Alzheimer's disease: in vitro and in vivo studies.

https://www.ncbi.nlm.nih.gov/pubmed/23414128


Olive Oil Phenols as Promising Multi-targeting Agents Against Alzheimer's Disease.

https://www.ncbi.nlm.nih.gov/pubmed/26092624


Alzheimers

Olive-oil-derived oleocanthal enhances b-amyloid clearance as a potential neuroprotective mechanism against Alzheimer's disease: in vitro and in vivo studies.

https://www.ncbi.nlm.nih.gov/pubmed/23414128


Leukemia

World olive center for Olive Oil health Benefits and Scientific Studies such as (Chronic Lymphocytic Leukemia)

olive oil rich in oleocanthal from the Lianolia Corfu variety (donated by the Dafnis family, The Governor) was given for a period of three months up to 1.5 years in a total of 30 patients with chronic lymphocytic leukemia or monoclonal gammopathy of unspecified significance at such a stage of the disease that chemotherapy was not yet necessary. The striking results showed a decrease or stabilization of white blood cells, a specific death of cancer cells and a fall in cancer markers in a significant number of patients. At the same time, olive oil improved a series of biochemical indices without any negative effect on patients.

https://aristoleo.com/world-olive-center-creates-the-biggest-olive-oil-competition-in-the-world/


Prostate cancer

Oleocanthal inhibits growth and metastasis by blocking activation of STAT3 in human hepatocellular carcinoma

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5190038/


Breast cancer

Oleocanthal Combined with Lapatinib Treatment Synergized against HER-2 Positive Breast Cancer In Vitro and In Vivo

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412724/

Enhancing athletic performance

Effect of virgin olive oil versus piroxicam phonophoresis on exercise induced anterior knee pain

https://pdfs.semanticscholar.org/071e/557c061736f836e291b25a68a3786fc082c0.pdf


Skin Cancer

Oleocanthal and oleacein contribute to the in vitro therapeutic potential of extra virgin oil-derived extracts in non-melanoma skin cancer.

https://www.ncbi.nlm.nih.gov/pubmed/29959992


Heart & Stroke (prevention)

Oleocanthal-rich extra virgin olive oil demonstrates acute anti-platelet effects in healthy men in a randomized trial similar to ibuprofen.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995573/

Side effects are more costly than the cost of the medicines themselves

https://medicalxpress.com/news/2019-02-pharmaceutical-side-effects-costly-health.html

Clinical and economic burden of adverse drug reactions

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853675/